Dinsdag 13 maart 2018

Locatie: Rode Kruis Den Bosch, Oude Dieze 12.


koffie van 19.45-20.00 uur

















Lezing Dr. Maurice Janssen

van 20.00 tot ca 21.30 uur


Removing the chiral blindfold of Mass Spectrometry by MS-PECD www.massspecpecd.com the Netherlands.

Mass Spectrometry is chirally blind, it cannot directly distinguish the two enantiomers of chiral molecules. Simultaneous, enantiomer-specific identification of chiral molecules in multi-component mixtures is extremely challenging.

Here we show how enantiomers may be differentiated by Mass-Selective PhotoElectron Circular Dichroism (MS-PECD) using an electron–ion coincidence imaging spectrometer [1-3]. Following an ionizing circular polarized laser pulse, ions and electrons are detected in coincidence on their respective time- and position sensitive detectors. The Mass-Selected PECD asymmetry reveals that the compound is chiral.

Here we will present the latest results with regard to the fundamental developments in PECD and the extension to analytical applications employing direct Mass Spectrometry analysis of multi-component mixtures of chiral molecules [4-6].

[1] C.S. Lehmann et al., J. Chem. Phys. 139, 234307 (2013)
[2] M.H.M. Janssen and I. Powis, Phys. Chem. Chem. Phys. 16, 856 (2014)
[3] M.M. Rafiee Fanood et al., Nature Communications 6, 7511 (2015)
[4] M.H.M. Janssen. The Analytical Scientist, May, 44 (2016)
[5] M.H.M. Janssen and I. Powis, Current Trends in Mass Spectrometry, May, 16 (2017)
[6] www.massspecpecd.com



Directe massaspectrometrie
van chirale moleculen.

Dr. Maurice Janssen

Founder and CEO of MassSpecpecD BV